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Gs/Gq Signaling Switch in Cells Defines Incretin Effectiveness in Diabetes
Combined interventions targeting MPC dysfunction, ROS buffering systems such as the Nrf2GSH axis, or mitophagy pathways including PINK1, may disrupt the self-sustaining signalmetabolism circuit and offer a strategy to delay or reverse acquired therapeutic resistance
Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ